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Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:

It had been only within the nineteen nineties however, when nanotechnology had Highly developed into a level where by single molecules could be manipulated, that the 1st experimental gadgets started to look.

, Groningen researchers current the final results in their endeavours to make labs much more sustainable and provide methods for other labs. 

Unfortunately, For several years right after Iijima’s report, the creation of thoroughly clean nanotubes was cumbersome. In 1996, having said that, the group of Richard Smalley at Rice College managed to produce solitary-walled carbon nanotubes at high produce. Soon following, I contacted Smalley, and we chose to sign up for forces to measure the transport via a single carbon nanotube.

We produce position-of-care diagnostics exam of neglected tropical disorders in resource-limited configurations, depending on Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.

The coiled-coil on the human Rad50 DNA restore protein contains precise segments of improved flexibility

Since 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. Recently his investigate has centered on learning mobile division with microorganisms on chip, whilst his ultimate fascination is inside the direction of noticing synthetic cells.

Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative vogue

In 1993, as being a young and keen affiliate professor at Delft College of Know-how, I had initially targeted the investigate initiatives of my group on measuring the electrical conductance of just one conducting-polymer molecule. Inside two years, we experienced designed a device in which just one wire of a phthalocyaninepolysiloxane polymer was linked amongst two intently spaced steel nanoelectrodes.

But carbon nanotubes have remained a exploration subject matter of considerable fascination to a lot of. Indeed, the outlook on employing carbon nanotubes to construct sensible devices, in areas for example radio-frequency electronics, digital electronics and flexible electronics, continues to be shiny.

FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division

Later on we spoke once more briefly for the reason that Dekker felt that our discussion of his religion quickly grew to become purely philosophical, While Additionally, it concretely can help him in his function.

Visualization of unstained DNA nanostructures with Highly developed in-target transmission electron microscopy procedures

Sound-condition nanopores have proven ceesdekker.net to generally be a shockingly multipurpose probe for solitary-molecule Examination of DNA. I will explain a few of our current findings – specifically DNA knots – and also our initiatives to expand the abilities of solid-point out nanopores even further more, in the course of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.